OPTIEUM BIOTECHNOLOGIES

Revolutionizing Immunity – Optimizing CAR-T for Breakthrough Therapies

ABOUT US

CAR that unlocks the full potential of T-cells
We are driving the evolution of next-generation CAR-T cell therapy with precision-engineered CAR constructs. Our CAR discovery engine focuses on optimizing the binding domain of CAR to enhance immune cell function, delivering robust therapeutic efficacy. Optieum is pushing the boundaries of solid tumor treatment powered by next-generation CAR constructs.

SCIENCE

CAR Discovery Engine – Eumbody System
Our core platform technology utilizes empirical methodologies to identify optimized CAR, accelerating the development of advanced CAR-T cell therapies.

Through our novel approach, our CAR discovery process dynamically harmonizes scFv sequences via empirical evaluation, significantly enhancing the functional capabilities of T cells.

T-cells are a crucial part of the immune system, which require a certain level of signals to be activated. Identifying the precise level of stimulation that triggers T-cells to become fully and appropriately active is important in both immunology and therapeutic approaches like CAR-T cell therapy.

Our next-generation CAR constructs are engineered to achieve the optimal activation threshold for T-cells to ensure precise and efficient immune responses, demonstrating superior proliferative capacity, preventing antigen escape, and exhibiting exceptional reactivity against advanced tumor profiles.

OUR PIPELINE

PROGRAM-1FAPa

Discovery Pre-Clinical Phase 1
INDICATIONS
solid tumor, cancer associated fibroblast

PROGRAM-2CD19

Discovery Pre-Clinical Phase 1
INDICATIONS
hematological malignancies, autoimmune disorders

PROGRAM-3Discovery

Discovery Pre-Clinical Phase 1
INDICATIONS
Undisclosed

OUR TEAM

Leadership

Shun Nishioka
President & CEOShun Nishioka
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Stewart Craig
CTOStewart Craig
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Kenji Nakamaru
Head of R&D, Vice PresidentKenji Nakamaru
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Afsana Islam
Manager of Molecular Bioscience, Principal ScientistAfsana Islam
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Larina Shen
Manager of Cellular Bioscience, Principal ScientistLarina Shen
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Board of Directors

Jonathan Yeh
Representing Saisei VenturesJonathan Yeh
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Yuto Torii
Representing Keio Innovation InitiativesYuto Torii
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Yusuke Miyazaki
Representing ANRIYusuke Miyazaki
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Shun Nishioka
President & CEOShun Nishioka
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Chiho Noda
AuditorChiho Noda
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Scientific Founder

Toshiki Ochi
Co-Founder & Advisor, Lecturer at Ehime UniversityToshiki Ochi
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